IFNA1 and Zika virus infectious disease: A recombinant NS3 mutant ZIKV encoding a mutated 14-3-3-binding motif (64-RLDP-67 → 64-KIKP-67) showed enhanced cytokine and ISG induction and reduced viral replication, compared to the parental virus, supporting the importance of RLR/14-3-3 inhibition for IFN antagonism during the ZIKV infection [57].