Finally, to determine whether the effects of copper sulfate were cell type-specific, we compared its effects on HIF-1α, p53, and DEC1 expression in HEC-1-A human endometrial adenocarcinoma, HEK293 human embryonic kidney, A549 human pulmonary adenocarcinoma, and Beas-2B immortalized normal human bronchial epithelial cells with those in HeLa cells (Figure 8). Here, HIF1A is linked to endometrium adenocarcinoma.