TP73-AS1 and butyrate dehydrogenase 2 (BDH2) were both up-regulated in esophageal squamous cell carcinoma (ESCC) tissue samples, while the expression of TP73-AS1 was obviously correlated both with tumor lymph node metastasis (TNM) stage and tumor location, BDH2 expression was only statistically associated with TNM stage. This evidence concerns the gene BDH2 and neoplasm.