TP53 and cancer: Numerous animal experiments have confirmed the important role of p53 in inhibiting the progression of cancer [33,34], for example, in 2017, Yao et al. [35] found that Boschniakia rossica polysaccharide (BRP) could increase the expression of p53, which could further lead to the activation of caspase-3, while decreasing the ratio of Bcl-2 to Bax could ultimately promote the apoptosis of laryngeal cancer cell.