TP53 and neoplasm: Meanwhile, some researches have demonstrated that restoring the functions of p53 and its mediated downstream signaling pathway contribute to the induction of cancer cell apoptosis, for instance, Yee-Lin et al. [10] found that Nutlin-3 could inhibit the interaction of p53 with murine double-minute type 2 protein (Mdm2) and activate p53-mediated tumor-inhibiting pathway in NPC cells [11].