In the study of mice heart, Hafner et al. [9] demonstrate that Sirt3 can regulate the opening of mPTP by deacetylating acetylated cyclophilin D. Recently, Sirt3 has been associated with neurocognitive performance and pathological changes (amyloid-β and τ levels) in the mice model of Alzheimer’s disease [32]. This evidence concerns the gene SIRT3 and Alzheimer disease.