For early‐stage CRC, as shown in Table 2 the algorithm comprised 12 proteins, 8 of which were identical with algorithm from all stages, that is, AREG, CEA, GZMB, ITGAV, KRT19, MCP1, PON3, TR, and additionally mannan‐binding lectin serine protease 1 (MASP1), retinoic acid receptor responder protein 2 (RARRES2), protein S100‐A4 (S100A4), and tartrate‐resistant acid phosphatase type 5 (TRAP), respectively. This evidence concerns the gene AREG and colorectal carcinoma.