NT5E and cancer: Overexpression of an ecto-5’-nucleotidase (CD73), the enzyme that dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine, within the cancer microenvironment, was recognized as the leading candidate in the generation of a strong immunosuppressive and pro-angiogenic adenosine halo, that facilitates cancer onset and progression, reviewed in [4,5, 6, and 7].