Comparative gene expression analysis of a malignant peripheral nerve sheath tumor TH06_0645_S01 and neurofibroma TH06_0646_S01 with loss of NF1 (OMIM 162200) revealed overexpression of sonic hedgehog signaling present in this tumor type.23 We also identified overexpression of receptor tyrosine kinases ERBB3 (OMIM 190151) and EGFR (OMIM 131550) in these tumors. The gene discussed is ERBB3; the disease is plexiform neurofibroma.