While it is unknown whether PI3K/AKT/mTOR and JAK/STAT pathways interact in DIPG, these pathways may be coactivated as a result of PI3K mutations in meningiomas.22 Because the interaction of these 2 pathways in DIPG is not known, we did not count this sample as having concordant DNA and RNA findings. This evidence concerns the gene AKT1 and diffuse intrinsic pontine glioma.