MTOR and acute lymphoblastic leukemia: The overexpression of PI3K/AKT/mTOR and B-cell receptor signaling pathway genes may be indicative of a progenitor B-cell state assumed by the leukemia cells.16 Similarly, another acute lymphoblastic leukemia sample (TH01_0129_S01) harbored a BCR–ABL (OMIM 151410) fusion.