Further silencing of MCPIP1 reversed the up-regulation of matrix metalloproteinase (MMP) 2 (MMP2) and MMP9 along with the high apoptotic rate in VSMCs induced by Ang-II, indicating that up-regulated MCPIP1 in AAA is associated with VSMCs apoptosis and MMPs production. The gene discussed is ZC3H12A; the disease is triple-A syndrome.