It has been hypothesized that dysfunction of tight junction among capillaries resulting in BBB dysfunction and lead to dementia.[15] Drugs like memantine and cholinesterase inhibition have been proven significantly effective in treating Alzheimer's disease (AD), and; therefore, are labeled for this indication; however, they are not recommended for the treatment of VaD either regulate bodies or guideline shops due to their overall low effectiveness and possible side effects.[16]. This evidence concerns the gene BCHE and Alzheimer disease.