IFNG and Opportunistic infection: The autoantibody against IFN-γ has also been recognized as a cause of both adult-onset immunodeficiency and a risk factor for infections due to opportunistic pathogens, including Cryptococcus neoformans, Histoplasma capsulatum, Burkholderia spp, Talaromyces (Penicillium) marneffei, and disseminated salmonellosis, especially in Asian patients.[1,2] However, anti-IFN-γ autoantibodies have not previously been associated with Bacillus cereus infections in the absence of other opportunistic infections.