ESR2 and non-small cell lung carcinoma: We understand our systematic review to be an extension and update to the meta-analysis by Zhuang Luo and the meta-analysis by Lihong Ma.[22,23] LUO suggested ERβ was significant associated with good overall survival in NSCLC patients on univariate analysis, while Ma get an conclusion that ERβ overexpression indicates no relationship of prognosis.