Another meta-analysis addressed that no association between Trp64Arg polymorphism in ADRB3 and susceptibility to GDM was found in overall population (Arg vs Trp: OR = 1.20, 95%CI = 0.99–1.47, P = .16; Trp/Arg+Arg/Arg vs Trp/Trp: OR = 1.22, 95%CI = 0.99–1.50, P = .11).[17] However, Trp64Arg polymorphism in ADRB3 had a certain association with susceptibility to GDM in subgroup analysis on European Caucasian.[17]. The gene discussed is ADRB3; the disease is gestational diabetes.