INS and obesity due to melanocortin 4 receptor deficiency: All these indicated that a series of factors including advanced age, obesity, decreased islet function, impaired glucose tolerance, and dyslipidemia increase the risk of GDM, which is consistent with previous reports.[22–24] Overweight and obese pregnant women are often accompanied by hyperlipidemia, etc., all of which can aggravate the severity of insulin resistance and increase the incidence of GDM.[25,26] The lower the FINS, the worse hypoglycemic activity Insulin cells have, which leads to abnormal OGTT.