CD274 and renal cell carcinoma: Improved efficacy with anti–PD-1/PD-L1 combinations in the 1 L setting have also been reported for pembrolizumab plus axitinib (KEYNOTE-426) [24], nivolumab plus ipilimumab (CheckMate 214) [14], and atezolizumab plus bevacizumab (IMmotion151) [30], highlighting the rapidly evolving treatment landscape in advanced RCC.