Whereas human patients exhibiting generalized glucocorticoid resistance have genomic mutations in the LBD of the GR, the treated dog of this case harbored an alternative splicing variant GR. This could occur only in peripheral blood mononuclear cells (PBMCs) from this dog; if other tissues had GRs with a normal splicing pattern, generalized glucocorticoid resistance should not be observed. This evidence concerns the gene NR3C1 and glucocorticoid resistance.