Whereas additional studies are required to understand precisely how CSPP1 expression in the spermatids involves in sperm head shaping and how obesity leads to declines in CSPP1 expression, our immediate goal was to set the stage for assessing the correlation of CSPP1with obesity associated asthenozoospermia and teratozoospermia. Here, CSPP1 is linked to obesity due to melanocortin 4 receptor deficiency.