Mayank et al. [42] identified 667 different proteins from normozoospermic and asthenozoospermic sperm samples, and 5 proteins which were significantly down-regulated in asthenozoospermia containing diversiform nodes related to sperm motility, such as Ninein, Fascin-3 and Plexin-B2. The gene discussed is PLXNB2; the disease is Reduced sperm motility.