According to the results of univariate logistic regression and the previous studies about the impact of metabolic syndrome on CRC [23], we adjusted for WHR, SBP, DBP, LDL-C, HDL-C, CEA, and family history of CRC in multivariate logistic regression analysis (sample size 200), the results still showed that FABP4 and FABP6 are independent risk factors for CRC development (adjusted odds ratio 1.916; 95%CI 1.340–2.492; P < 0.001; adjusted odds ratio 2.162; 95%CI 1.046, 1.078); P < 0.001, respectively) (Table 4). This evidence concerns the gene FABP4 and metabolic syndrome.