CTH and neoplasm: Overexpression of cystathionine-gamma-lyase (CSE), acystathionine-beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) which ultimately leads to increased amounts of H2S, which augmented tumour growth and distinct metastasis by activating cellular bioenergetics, proliferative, migratory, and invasive signalling pathways [35].