The significantly high uptake of [111In]In-DOTA-cetuximab in EGFR-highly-overexpressing HCC827 in comparison with xenograft tumors with low to moderate EGFR expression levels suggests the potential of [64Cu]Cu-DOTA-cetuximab immuno-PET for detection of EGFR expression status in NSCLC. Here, EGFR is linked to non-small cell lung carcinoma.