Serum autotaxin levels increase with progression of liver fibrosis caused by various etiologies such as chronic hepatitis C, chronic hepatitis B, non-alcoholic steatohepatitis (NASH), and PBC [11–15], and serum autotaxin level is also associated with pruritus in patients with cholestasis [16]. The gene discussed is ENPP2; the disease is Hepatic fibrosis.