Univariate analysis showed that hemoglobin (P = 0.003), eosinophil count (P = 0.003), γ-glutamyl transpeptidase (P = 0.003), albumin (P < 0.001), estimated glomerular filtration rate (P = 0.022), PBC (P = 0.006), and hepatic encephalopathy or esophageal varices (P = 0.002) were each significantly associated with pruritus (Table 1). This evidence concerns the gene ALB and esophageal varices.