Zinc finger 750(ZNF7509) is a transcription factor controlling epidermaldifferentiation and an upstream regulator of MPZL3.Autosomal dominantly inherited SD-like dermatitis hasbeen identified in a frameshift mutation in ZNF750 [24].The functional pathway of ZNF750-MPZL3 has beensuggested to play an important role in the pathogenesis ofSD [25]. The gene discussed is ZNF750; the disease is skin disorder.