In previous work we found that the GATOR1 complex downregulates TORC1 activity to facilitate meiotic entry in Drosophila ovarian cysts (Deutschbauer et al., 2002; Jordan et al., 2007; Neklesa and Davis, 2009; Spielewoy et al., 2010; Wei et al., 2014). Here, CRTC1 is linked to Ovarian cyst.