This gene polymorphism is linked to many inflammatory and neoplastic diseases such as basal cell carcinoma, Graves’ disease (IL-2 -330T/G), hepatocellular carcinoma; multiple sclerosis IL-2 (-330 T/T), Behçet’s disease where the IL-2 (-330 GT) genotype shows susceptibility and the IL-2(-330 T/T) genotype shows a preventive impact, nasopharyngeal carcinoma IL-2 (-330 T/G), neuroendocrine tumors, and asthma IL-2 (-330) and IL-2 (+166) [26–33]. The gene discussed is IL2; the disease is hepatocellular carcinoma.