Our research indicates that the standard low‐Phe, high‐acid AA diet used in studies with the Pahenu2 murine model of Pah deficiency induces metabolic stress and increases renal workload based on greater renal mass, fluid intake, and polyuria in both Pah−/− and wild‐type (WT) mice (Solverson et al. 2012). This evidence concerns the gene PAH and hyperinsulinemic hypoglycemia, familial, 4.