https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%2520Y%255BAuthor%255D%26cauthor=true%26cauthor_uxml:id=28423670 et al reported that Fusobacterium nucleatum activates beta‐catenin signalling in CRC via a TLR4/P‐PAK1 cascade.14 However, it has been reported that TLR4‐deficient C3H/HeJ mice developed more tumours relative to TLR4‐normal C3H/HeN mice.15 This suggests that TLR4 may also have a role in inhibiting tumorigenesis. This evidence concerns the gene TLR4 and neoplasm.