TLR4 pathway‐mediated immune response is an important mechanism that aggravates intestinal injury in mouse ulcerative colitis models.30 In the present study, ApcMin/+ intestinal adenoma mice were generated on TLR4‐sufficient and TLR4‐deficient backgrounds to investigate the carcinogenic effect of TLR4 by comparing mice survival, peripheral blood cells, bone marrow haematopoietic precursor cells and numbers of polyps in the guts of ApcMin/+ WT and ApcMin/+ TLR4 mice. This evidence concerns the gene TLR4 and ulcerative colitis.