VEGFA and osteoarthritis: An array of increased inflammatory markers has also been reported in osteoarthritis which include several interleukins, vascular endothelial growth factor (VEGF), C-reactive protein (CRP), TNF-α, nitric oxide, prostaglandins, and leukotrienes and their presence may accelerate the deterioration of cartilage (Abramson and Krasnokutsky 2006).