There is increasing evidence of the importance of LOXs in driving tumor growth and progression; in particular, many studies indicate that the HIF-1/LOXs’ axis is a crucial mechanism in driving the tumor cell proliferation, the epithelial–mesenchymal transition (EMT), the formation of pre-metastatic niches, and the cancer cells migration and invasion [27, 56, 72–75]. The gene discussed is HIF1A; the disease is neoplasm.