The biological mechanisms underlie serum total calcium and blood pressure maybe attribute to a direct effect on vascular by enhanced vascular resistance (42), interaction between serum calcium and other cations (43), alteration in extracellular binding of calcium (44), renal vasoconstriction causing kidney dysfunction (45), and hyperactivity of renin-angiotensin system from hyperparathyroidism (46). This evidence concerns the gene REN and hyperparathyroidism.