McGrath et al. (114) also reported that the patients with non-eosinophilic mild asthma had less bronchial hyperresponsiveness than those with airways eosinophilia and Arron et al. (115) also demonstrated an inverse relationship between an IL13-high gene signature (T2-high asthma) and bronchial hyperresponsiveness suggesting that T2-low/non-eosinophilic disease is associated with less physiological abnormalities. The gene discussed is IL13; the disease is asthma.