ODZ1 (Teneurin-1, TNM1, TENM1), a philogenetically conserved type II transmembrane protein, has been associated to the migratory capacity of GBM cells by upregulating the RhoA-ROCK pathway that results in cytoskeletal remodeling, cell migration and invasion of peritumoral parenchyma (14). Here, TENM1 is linked to glioblastoma.