Of those, seven proteins, caspase-3, CD69, prolactin, epidermal growth factor (EGF), chemokine (C-C) ligand 24 (CCL24), amphiregulin (AREG), and heparin-binding EGF (HB-EGF) were highly expressed in the Grade I meningioma samples (Figure 1B), while, the other seven proteins, vascular endothelial growth factor D (VEGF-D), transforming growth factor alpha (TGF-α), E-selectin, B-cell activating factor (BAFF), interleukin-12 (IL-12), chemokine (C-C motif) ligand 9 (CCL9), and Growth Hormone were reduced in the meningioma serum samples, compared to healthy control subjects (Figure 1C and Table 1). The gene discussed is AREG; the disease is meningioma.