TNF and cancer: Moreover, the KEGG pathway enrichment analysis suggested that these target genes were significantly correlated with “TNF signaling pathway,” “Small cell lung cancer,” “Rap1 signaling pathway,” “PI3K-Akt signaling pathway,” “mTOR signaling pathway,” “FoxO signaling pathway,” “Focal adhesion,” “ECM-receptor interaction,” and some other cancer-related pathways (Figure 10A).