CD200R/CD200—immunosuppressive signal transmission, macrophages inhibition, Tregs induction and tumor-specific T cells inhibition (93).Expression of CD200 on human AML cells (94)—worse overall survival of some AML subsets (83).Blocking of CD200—enhanced cytotoxicity of NK cells, restored proliferative capacity of T cells, dampens tumor-reactive immune responses (95), but also favors tumor progression due to enhanced pro-tumorigenic inflammation (96). Here, CD200R1 is linked to acute myeloid leukemia.