HMGB1 and neoplasm: Regarding immunogenicity, anthracyclines, oxaliplatin, mafosfamide, bortezomib, and some other types of chemotherapy agents are effective in inducing CRT and HSP exposure (11, 12, 32, 47, 59, 61), as well as ATP secretion (31, 52, 55) and HMGB1 release (12, 73) from various tumor cells including leukemias.