The ability of PRS231 to associate with obesity per se was higher in the QFS discovery sample (AUCadj = 0.704) than that observed in the QFS validation sample (AUCadj = 0.661) and in the FAS replication sample (AUCadj = 0.619) (Figure 3A). The gene discussed is FAS; the disease is obesity due to melanocortin 4 receptor deficiency.