They analyzed the promoter methylation of ATP binding cassette subfamily A member 1 (ABCA1), TIMP metallopeptidase inhibitor 1 (TIMP1), and acetyl-CoA acetyltransferase 1 (ACAT1) and observed significant alterations in the peripheral blood of atherosclerosis patients (Ma et al., 2016). The gene discussed is TIMP1; the disease is atherosclerosis.