SOD2 and hypertensive disorder: There are also epigenetic factors that can influence the appearance of hypertension in adults, such as hypermethylation of genes, including superoxide dismutase-2 (SOD2) or Granulysin, or increased levels of histone acetylation at the promoter of the endothelial oxide synthetase gene (eNOS) (Wang et al., 2018b).