CLDN5 and dilated cardiomyopathy: Koczor et al. (2013) also studied the differential methylation patterns in patients with dilated cardiomyopathy, which is characterized by congestive HF. Computational analysis detected few differentially methylated gene promoters (AURKB, BTNL9, CLDN5, and TK1). This study provides relevant information on DNA methylation and altered expression in dilated cardiomyopathy that would help in treatment (Koczor et al., 2013).