TNFRSF1B and neoplasm: Moreover, TNFR2-deficient mice reveal significant tumor growth, and the presence of TNFR2 associates with the accumulation of CD8+ TILs and CD8+ T-cell IFN-γ synthesis, suggesting TNFR2 potentiation on CD8+ TILs has a role in anti-tumor activities (37, 38).