Moreover, TNFR2-deficient mice reveal significant tumor growth, and the presence of TNFR2 associates with the accumulation of CD8+ TILs and CD8+ T-cell IFN-γ synthesis, suggesting TNFR2 potentiation on CD8+ TILs has a role in anti-tumor activities (37, 38). This evidence concerns the gene CD8A and neoplasm.