Globally, the amount of intratumoral CD8+ T cells increased in post-treatment tumor biopsies compared with pre-treatment ones, although this change did not reach statistical significance (mean ± SEM 597.9 ± 132.7 vs. 731.5 ± 159.0 CD8+ cells/mm2 in pre-treatment and post-treatment biopsies, respectively; p = 0.2114; Figure 1A). Here, CD8A is linked to neoplasm.