Intriguingly, a selective significant increase of tumor-associated CD8+ T cells in post- vs. pre-vaccine samples was observed in the naïve/CT/RT group (mean ± SEM 533.2 ± 201.7 vs. 878.6 ± 220.3 CD8+ cells/mm2 in pre-treatment and post-treatment biopsies, respectively; p = 0.0195, Figure 1B, Supplementary Table 1) compared to the immuno_treated one (mean ± SEM 681.0 ± 1,649.7 vs. 542.4 ± 224.9 CD8+ cells/mm2 in pre-treatment and post-treatment biopsies, respectively; p = 0.2969; Figure 1B, Supplementary Table 1). Here, CD8A is linked to neoplasm.