In 11 out of the 16 cases indagated the sites of tumor biopsies taken before and after vaccination were of the same type, i.e., soft tissue/nodal or visceral, according to the classification provided in Bartlett et al. (27), thus avoiding any statistically significant imbalance in the level of CD8 expression in the selected pre-treatment sample cohorts. The gene discussed is CD8A; the disease is neoplasm.