Notably, the pqs QS system is active during the infection (Collier et al., 2002; Barr et al., 2015), and while P. aeruginosa mutants impaired in the las QS system are frequently isolated from CF patients (Hoffman et al., 2009; Feltner et al., 2016), the highest proportion of P. aeruginosa strains isolated from CF lung are proficient for AQs production (Guina et al., 2003; Jiricny et al., 2014). Here, LIAS is linked to cystic fibrosis.