Another study show reveals the association of NF-κB, MMP-9, and MICA in pituitary adenomas, the higher expressions of MICA, MMP-9, and NF-κB in mRNA and protein levels in pituitary adenomas relative to healthy tissues; which found that the upregulation of NF-κB can activate the expression of MICA and increase MMP-9 expression to hydrolyze MICA into sMICA to facilitate tumor immune escape (131). The gene discussed is MICA; the disease is neoplasm.