Specifically, tumor suppressor proteins that negatively regulate mTOR pathway, such as LKB1, PTEN, TSC1/2, and AMPK, stimulate autophagy, while oncogenes that activate mTOR pathway, such as Ras, class I PI3K, AKT, and Rheb, inhibit autophagy, indicating the contribution of autophagy to cancer growth or tumor suppression. This evidence concerns the gene MTOR and neoplasm.