MMP13 and chondrosarcoma: Recently, α-MSH was reported to attenuate TNF-α-induced matrix metalloproteinase-13 expression by regulating activation of p38 and NF-κB in HTB-94 cells (a human chondrosarcoma cell line expressing MC1R), indicating that α-MSH might be used to prevent matrix metalloproteinase-13-mediated collagen degradation (153).