In the case of NRG1 rs6994992, given that significant allele frequency differences were observed for the risk T allele between the Han Chinese population (60%) and the European population (37%), it is possible that such population-specific allele frequencies may account for some of the reasons for the ethnic difference in the relationship between NRG1 rs6994992, schizophrenia and creativity (i.e., allele frequency may moderate the relationship between NRG1 rs6994992, schizophrenia and creativity). This evidence concerns the gene NRG1 and schizophrenia.