Recent study has shown that BNIP3-, NIX-, and FUNDC1-mediated mitophagy plays a critical role in the treatment of lipid metabolism, hepatocellular carcinoma, hepatic insulin resistance, alcoholic liver disease, hepatic steatosis, and liver injury (Danielle et al., 2012; Williams and Ding, 2015; Chao et al., 2018; Liu et al., 2018; Li et al., 2019; Yu et al., 2019b). The gene discussed is FUNDC1; the disease is Insulin resistance.