FUNDC1 and Insulin resistance: Wu et al. (2019) have found that impaired mitophagy can accelerate macrophage infiltration in white adipose tissue in high-fat diet–fed mice with FUNDC1 knockout. They have also demonstrated that impaired mitophagy can promote macrophage infiltration to activate MAPK signal pathway and inflammatory response to impair mitochondrial quality control, subsequently causing insulin resistance and hepatic steatosis (Wu et al., 2019).