Evaluation of specific subtypes of CD4+ T cells in IRI-induced AKI indicates that TH1 cells tend to worsen kidney damage, since mice KO for IL-12, a cytokine known to induce TH1 cells, are protected from IRI, whereas in mice KO for IL-4, cytokine known to induce TH2 cells, kidney damage is exacerbated (Marques et al., 2006; de Paiva et al., 2009). This evidence concerns the gene CD4 and acute kidney injury.