From the integrated drug target prediction, GO, and pathway enrichment as well as network analyses, we speculated that the antitumor effects of ZJP on HCC might be associated with the roles of its key targets including MAPK1, PIK3CA, EGFR, CCND1, and NFKBIA in regulating HCC cell proliferation and survival. Here, PIK3CA is linked to hepatocellular carcinoma.