Recent studies have found that TMEM16A (also known as Dog1) is highly expressed in different sources of ICC and that the intestinal ICC network in TMEM16A gene knockout mice develops normally; however, the slow-wave activity of small intestinal smooth muscle disappears (Isozaki et al., 1997; He et al., 2001; Hwang et al., 2009). Here, ANO1 is linked to intrahepatic cholangiocarcinoma.