In esophageal, pancreatic, breast, and lung cancer cells, plumbagin reduced cell viability, invasion, and migration through inhibiting the activity, phosphorylation, and signaling of STAT3 (Hafeez et al., 2012; Yan et al., 2013; Cao et al., 2018; Yu T et al., 2018). The gene discussed is STAT3; the disease is lung carcinoma.