In the disproportionality analysis, we found a statistically significant ROR for drugs used in cardiovascular disorders (beta-blockers, plain ACE inhibitors, RAS-acting agents, selective Ca2+ channel blockers, and alpha-blockers) but also for the single active substances (propafenone, doxazosin, metoprolol, bisoprolol, nebivolol, ramipril, irbesartan, losartan and diuretics, and hydrochlorothiazide and potassium-sparing agents). This evidence concerns the gene ACE and cardiovascular disorder.