Beta-blockers, plain ACE inhibitors, RAS-acting agents, selective Ca2+ channel blockers, peripherally acting antiadrenergic agents, hormone antagonists, as well as antiglaucoma preparations and miotics mostly regarding timolol in combinations were mainly involved with the occurrence of tinnitus (n = 15, n = 14, n = 10, n = 9, n = 4, n = 7, and n = 7, respectively). This evidence concerns the gene ACE and Tinnitus.