SHH and liver cancer: This pathway plays a major role in developmental processes (Chouldhry et al., 2014) and several studies have demonstrated that the activation of the SHH signaling pathway induces migration of various cell types including glioblastoma, liver cancer cells, fibroblasts, endothelial cells, monocytes as well as aortic SMCs (Dunaeva et al., 2010; Renault et al., 2010; Polizio et al., 2011; Chen et al., 2013; Yao et al., 2014; Chang et al., 2015).