PXN and neoplasm: These signaling pathways promote tumor metastasis changing the expression or activation of extracellular matrix proteases (such as MMPs), as well as cytoskeletal (cadherins, Arp2/3, N-WASP) and cell adhesion molecules (paxillin, integrins, and focal adhesion kinase) (Birchmeier et al., 2003; Cao et al., 2015; Demkova and Kucerova, 2018).