DUSP26 and Alzheimer disease: While the onset of this degeneration is driven by tauopathy in humans (Hertz, 1989; Parvizi et al., 2001; Geula et al., 2008; Grinberg et al., 2009; Simic et al., 2009), we were able to recapitulate the effects of AD-driven LC degeneration with the neurotoxin, DSP-4 in healthy rats.