FMR1 and fragile X syndrome: Rotschafer and Razak (2013) show broadened frequency tuning curves for individual neurons in auditory cortex in fmr1 KO mice, which may make FXS particularly sensitive to lateral inhibition effects. Alternatively, inhibitory interneuron dysfunction is characteristic of FXS (Cea-Del Rio and Huntsman, 2014), which may decrease lateral inhibition in FXS (Franco et al., 2017).